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SBI-0640756 1821280-29-8 SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
PF-CBP1 1962928-21-7 PF-CBP1 l is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains。
MRT68921 1190379-70-4 MRT68921 is an inhibitor of ULK1 and ULK2 (IC50s = 2.9 and 1.1 nM, respectively). Through its effects on ULK1, MRT68921 blocks autophagy in cells
Emricasan 254750-02-2 Emricasan is a potent irreversible pan-caspase inhibitor.
DTP3 1809784-29-9 DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway.
BV-6 1001600-56-1 BV6 induces autoubiquitination and subsequent proteasomal degradation of cIAP1 and cIAP2, and greatly sensitizes cells to TNF-induced necrosis.
Glasdegib 1095173-27-5 Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
Z-FA-FMK 197855-65-5 Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.
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