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| 品牌 | absin | CAS | 197855-65-5 |
|---|---|---|---|
| 分子式 | C21H23FN2O4 | 纯度 | ＞98% |
| 分子量 | 386.42 | 货号 | abs47028416 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an irreversible cysteine protease in | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Z-FA-FMK 197855-65-5
| 产品描述 | |
| 描述 | Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Z-Phe-Ala fluoromethyl ketone |
| 外观 | 白色固体 |
| 可溶性/溶解性 | DMSO : 71 mg/mL (183.7 mM) Ethanol : 32 mg/mL (82.8 mM) |
| 生物活性 | |
| 靶点 | cysteine protease |
| In vitro(体外研究) | Z-FA-FMK inhibits the degradation of fibrillar collagen by fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Z-FA-FMK efficiently blocks T cell proliferation induced by mitogens and IL-2 in vitro. |
| In vivo(体内研究) | Z-FA-FMK significantly increases pneumococcal growth in both lungs and blood in a mouse model of intranasal pneumococcal infection. Z-FA-FMK blocks reovirus infection of Ras oncogenic tumours and host heart tissues in severe combined immunodeficiency mice. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerInvasion/microenvironmentAngiogenesisECM enzymesCathespins CancerInvasion/microenvironmentECMCell adhesionOther CancerInvasion/microenvironmentECMExtracellular matrixOther NeuroscienceProcesses NeuroscienceCell Adhesion ProteinsMembrane Proteins Signal TransductionCytoskeleton / ECMExtracellular MatrixOther EnzymesECM Enzymes Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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