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Product Category详细介绍
| 品牌 | absin | CAS | 1809784-29-9 |
|---|---|---|---|
| 分子式 | C26H35N7O5 | 纯度 | ＞98% |
| 分子量 | 525.6 | 货号 | abs814545 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a selective GADD45β/MKK7 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
DTP3 1809784-29-9
| 产品描述 | |
| 描述 | DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | DTP 3 |
| 外观 | powder |
| 可溶性/溶解性 | DMSO ：100 mg/mL (190.26 mM) Water ：100 mg/mL (190.26 mM) |
| 生物活性 | |
| 靶点 | GADD45β,MKK7 |
| In vitro(体外研究) | DTP3 physically interacts with MKK7, both in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.21 in U266 cells and of 0.56 in KMS-12 cells. |
| In vivo(体内研究) | DTP3 (14.5 mg/kg/day) exhibits potent antitumor activity against MM in mouse plasmacytoma model. |
| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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