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| 品牌 | absin | CAS | 1962928-21-7 |
|---|---|---|---|
| 分子式 | C29H36N4O3 | 纯度 | 98% |
| 分子量 | 488.63 | 货号 | abs821407 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a highly selective inhibitor of the b | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
PF-CBP1 1962928-21-7
| 产品描述 | |
| 描述 | PF-CBP1 l is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM). |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | PF-06670910 |
| 可溶性/溶解性 | DMSO : 100 mg/mL |
| 生物活性 | |
| 靶点 | CREB |
| In vitro(体外研究) | PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson's disease. It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high. |
| 研究领域 | |
| 研究领域 | EpigeneticsTranscriptionTranscription Factors EpigeneticsTranscriptionDomain FamiliesHLH / Leucine ZipperHLH / Leucine Zipper ImmunologyInnate ImmunityTLR Signaling NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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