Carfilzomib (PR-171) 868540-17-4 Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.

ONX-0912(Oprozomib) 935888-69-0 Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.

LY-364947 396129-53-6 LY-364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II.

ICG-001 780757-88-2；847591-62-2 ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF

RKI-1447 1342278-01-6 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.

IPI-145 1201438-56-3 Duvelisib is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immuno

AZ3146 1124329-14-1 AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM); less potent to FAK, JNK1, JNK2, and Kit.

SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.