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XL-888 1149705-71-4 XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
CI-994 112522-64-2 CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM.
Carfilzomib (PR-171) 868540-17-4 Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.
ONX-0912(Oprozomib) 935888-69-0 Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.
LY-364947 396129-53-6 LY-364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II.
ICG-001 780757-88-2；847591-62-2 ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF
RKI-1447 1342278-01-6 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
IPI-145 1201438-56-3 Duvelisib is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immuno
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