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| 品牌 | absin | CAS | 112522-64-2 |
|---|---|---|---|
| 分子式 | C15H15N3O2 | 纯度 | ＞98% |
| 分子量 | 269.3 | 货号 | abs810443 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is an anti-cancer drug | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
CI-994 112522-64-2
| 产品描述 | |
| 描述 | CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 乙酰地那林；Acetyldinaline; Tacedinaline; PD 123654; Goe 5549 |
| 外观 | off-white Powder |
| 可溶性/溶解性 | DMSO : 26.9 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | HDAC1 ,HDAC2 ,HDAC3 |
| In vitro(体外研究) | CI-994 ( CI-994 inhibits growth of LNCaP cell with IC50 of 7.4 μM. CI-994 exerts activity against several tumor cell lines with greater cytotoxicity against the solid tumors relative to both the leukemia and normal fibroblast cell lines. CI-994 inhibits growth of rat leukemia BCLO cells with IC50 of 2.5 μM. |
| In vivo(体内研究) | CI-994 exerts demonstrated antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP. |
| 研究领域 | |
| 研究领域 | CardiovascularHeartHypertrophyOther EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass I Stem CellsSignaling PathwaysWntHDACs Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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