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Product Category详细介绍
| 品牌 | absin | CAS | 1201438-56-3 |
|---|---|---|---|
| 分子式 | C22H17ClN6O | 纯度 | ＞98% |
| 分子量 | 416.86 | 货号 | abs810399 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is an orally bioavailable | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
IPI-145 1201438-56-3
| 产品描述 | |
| 描述 | Duvelisib is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | IPI-145; INK1197 |
| 外观 | 白色至类白色粉末 |
| 可溶性/溶解性 | DMSO : 77 mg/mL (184.7 mM) |
| 生物活性 | |
| 靶点 | PI3Kα,PI3Kβ,PI3Kγ, PI3Kδ |
| In vitro(体外研究) | IPI-145 suppresses murine/human B-cell proliferation with EC50 of 0.5 nM/0.5 nM and also inhibits human T-cell proliferation with EC50 of 9.5 nM. |
| In vivo(体内研究) | IPI-145 (10 mg/kg, p.o.) shows well pharmacokinetics with Cmax and AUC of 390 ng/mL and 137 ng•h/mL in mouse and rat. IPI-145 (10 mg/kg) is active in murine DTH model with ~50% ear swelling. IPI-145 (10 mg/kg) demonstrates dose-dependent effect in rat collagen induced arthritis (CIA) model. IPI-145 prevents inflammation and protects joint bone and cartilage in the rat CIA model. IPI-145 (10 mg/kg,QD) demonstrates activity in rat adjuvant induced polyarthritis model. |
| 研究领域 | |
| 研究领域 | CancerCancer Metabolism CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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