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| 品牌 | absin | CAS | 780757-88-2；847591-62-2 |
|---|---|---|---|
| 分子式 | C33H32N4O4 | 纯度 | ＞98% |
| 分子量 | 548.63 | 货号 | abs810420 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a small-molecule antagonist of b-cate | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
ICG-001 780757-88-2；847591-62-2
| 产品描述 | |
| 描述 | ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. ICG-001 binds specifically to cyclic AMP response element-binding pro |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | ICG001；ICG 001 |
| 外观 | Off-white powder |
| 可溶性/溶解性 | DMSO ：100 mg/mL (182.27 mM) Ethanol ：10 mg/mL (18.22 mM) |
| 生物活性 | |
| 靶点 | Wnt/β-catenin |
| In vitro(体外研究) | PRI-724 binds specifically to CBP but not the related transcriptional coactivator p300, thereby disrupting the interaction of CBP with β-catenin. Treatment with PRI-724 selectively induces apoptosis in colon carcinoma cells but not in normal colonic epithelial cells and reduces in vitro growth of colon carcinoma cells. |
| In vivo(体内研究) | PRI-724 exhibits antitumor activity in the mouse xenograft models of colon cancer. The initial results of the Phase I clinic trial of PRI-724 has been disclosed publically. The drug exhibits an acceptable toxicity profile with only one dose-limiting toxicity of grade 3 reversible hyperbilirubinaemia. An Open-Label dose-escalation phase I/II study of PRI-724 for patients with advanced myeloid malignancies is still ongoing. |
| 研究领域 | |
| 研究领域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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