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详细介绍
| 品牌 | absin | 纯度 | Greater than 95% as determined by reduci |
|---|---|---|---|
| 货号 | abs04185 | 规格 | 10ug |
| 供货周期 | 现货 | 主要用途 | is produced by our E.coli expression sys |
| 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Recombinant Human BDNF Protein
| 产品描述 | |
| 描述 | Recombinant Human Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding His129-Arg247 is expressed. |
| 别名 | BDNF蛋白;Brain-Derived Neurotrophic Factor; BDNF; Abrineurin |
| 种属 | Human |
| 来源 | Escherichia coli. |
| 形态 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| 储存/保存方法 | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| 性能 | |
| 序列 | MHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYT KEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR |
| 标签 | No Tag |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
| 内毒素水平 | Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. |
| 活性 | Immobilized Human BDNF at 2ug/ml (100 μl/well) can bind Human TrkB-His . The ED50 of Human TrkB-His is 2-10 ug/ml . |
| 溶解方法 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 靶标 | |
| 背景说明 | Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. |
| Accession | P23560 |
| 研究领域 | |
| 研究领域 | Signal Transduction CardiovascularAtherosclerosisDiabetes associated CardiovascularAtherosclerosisThrombosisOther MetabolismTypes of diseaseDiabetes MetabolismTypes of diseaseObesity NeuroscienceDevelopment NeuroscienceProcesses NeuroscienceNeurology processGrowth and DevelopmentNeurotrophins NeuroscienceNeurology processNeurodegenerative diseaseHuntington's disease NeuroscienceNeurology processNeurodegenerative diseaseAlzheimer's diseaseOther |
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