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Recombinant human CTLA4(10ug)

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  • 产品型号:abs02003a
  • 厂商性质:生产厂家
  • 更新时间:2022-10-17
  • 访  问  量:587

详细介绍

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概述

描述

Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa. Purified CTLA4 protein is below the position of 26 kDa on SDS-PAGE gel under reduced condition.
CTLA4 protein is purified by proprietary chromatographic techniques.

Entrez Gene summary for CTLA4:

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

UniProtKB/Swiss-Prot: P16410 (CTLA4_HUMAN)

Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

别名

Cytotoxic T-lymphocyte protein 4 / CTLA4

形态

Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5

性能

保存方法

Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws.

序列

CTLA4-His-DYK (N-terminal 35 aa is predicted to be signal peptide): MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDHHHHHHHHDYKDDDDK

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