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SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
AVL-292 1202757-89-8 AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk currently being evaluated in a Phase 1b clinical trial in relapsed.
INK-128 1224844-38-5 INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; 200-fold less potent to class I PI3K isoforms.
GSK-2636771 1372540-25-4 GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a.
Molibresib 1260907-17-2 GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4).
LY2886721 1262036-50-9 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
MC1568 852475-26-4 MC1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6.
GSK126 1346574-57-9 GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM.
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