GSK-2636771 1372540-25-4

简要描述：GSK-2636771 1372540-25-4
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a.

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详细介绍

品牌	absin	CAS	1372540-25-4
分子式	C22H22F3N3O3	纯度	＞98%
分子量	433.42	货号	abs810341
规格	5mg	供货周期	现货
主要用途	is a potent, orally bioavailable	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

GSK-2636771 1372540-25-4

产品描述
描述	GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a.
纯度	>98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	GSK 2636771,GSK-2636771
外观	Powder
可溶性/溶解性	DMSO 28 mg/mL (64.6 mM)
生物活性
靶点	PI3Kβ
In vitro(体外研究)	GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. GSK2636771 significantly decreases cell viability in p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines, and leads to a marked decrease of AKT phosphorylation only in the control prostate and breast cancer cell lines.
In vivo(体内研究)	GSK-2636771 decreases phosphorylated protein kinase Akt (Ser473) levels in these xenograft models. GSK-2636771 (100 mg/kg) do not increase glucose/insulin levels in mice.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

GSK-2636771 1372540-25-4温馨提示：本产品仅作科研实验使用，不支持临床等研究

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