INK-128 1224844-38-5

简要描述：INK-128 1224844-38-5
INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms.

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品牌	absin	CAS	1224844-38-5
分子式	C15H15N7O	纯度	＞98%
分子量	309.33	货号	abs810344
规格	5mg	供货周期	现货
主要用途	is a potent and selective mTOR inhibitor	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

INK-128 1224844-38-5

产品描述
描述	INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM; >200-fold less potent to class I PI3K isoforms.
纯度	>98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	沙帕色替；INK 128; INK128;Sapanisertib; MLN0128
外观	白色至类白色固体
可溶性/溶解性	DMSO : 58 mg/mL (187.5 mM) Ethanol : 2 mg/mL (6.46 mM)
生物活性
靶点	mTOR；mTORC1；mTORC2；PI3Kα；PI3Kγ；PI3Kδ
In vitro(体外研究)	INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.
In vivo(体内研究)	In a ZR-75-1 breast cancer xenograft model, INK 128 shows tumor growth inhibition efficacy at a dose of 0.3 mg/kg/day. Daily, oral administration of INK 128 inhibits angiogenesis and tumor growth in multiplexenograft models.

研究领域
研究领域	CancerCell cycleCell cycle inhibitorsOther CardiovascularHeartCardiogenesisTranscription factors/regulators Cell CycleCell Cycle InhibitorsOther EpigeneticsDNA / RNADNA Damage & RepairDNA Damage ResponseDNA Damage Recognition MetabolismTypes of diseaseObesity NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery

INK-128 1224844-38-5温馨提示：本产品仅作科研实验使用，不支持临床等研究

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