APD 668 832714-46-2 APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.

AF 353 865305-30-2 AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

ELN 441958 913064-47-8 ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM.

PI3065 955977-50-1 PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR.

CDK4-IN-1 1256963-02-6 CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC5015 uM)

LY2409881 triHCl 946518-60-1 LY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

LCL161 1005342-46-0 LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.

Fimepinostat 1339928-25-4 Fimepinostat potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes.