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| 品牌 | absin | CAS | 1784-03-8 |
|---|---|---|---|
| 分子式 | C14H23ClN4O4S | 纯度 | ＞98% |
| 分子量 | 378.87 | 货号 | abs47027847 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is an inhibitor of anaphase-promoting c | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
TAME hydrochloride 1784-03-8
| 产品描述 | |
| 描述 | TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | NA-P-甲苯磺酰-L-精氨suan甲酯盐酸盐;Tos-Arg-OMe HCl；TOS-ARG-OME hydrochloride |
| 外观 | White Powder |
| 可溶性/溶解性 | DMSO : 155 mg/mL (409.11 mM;) H2O : ≥ 100 mg/mL (263.94 mM) |
| 生物活性 | |
| 靶点 | APC |
| In vitro(体外研究) | TAME shows inhibitory effect on APC activation when added to mitotic Xenopus extract. TAME (1-200 μM) inhibits Cdc20 association with mitotic APC and also inhibits Cdh1 association with interphase APC. TAME significantly inhibits crosslinking of the IR peptide to Cdc27 and Cdc16 but only slightly reduces crosslinking to Cdc23 and Apc7 at 20 µM; TAME strongly inhibits crosslinking to all APC subunits at 200 µM. TAME also inhibits binding of wild type Cdc20 to the APC, but not binding of a ΔIR mutant. TAME (200 μM) induces Cdc20 dissociation from the APC in mitotic Xenopus extract calls for APC-dependent ubiquitination. TAME induces Cdc20 dissociation from the APC by promoting Cdc20 ubiquitination, but the dissociation can be suppresses by Cyclin B1. TAME terminates cyclin B1 ubiquitination prematurely. TAME interacts with ATP by β and γ phosphate and the adenine ring of ATP. TAME in combination with the Mg(II) ion accelerates the ATP hydrolysis process. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell division CancerOncoproteins/suppressorsTumor suppressorsPTC & Wnt pathway CardiovascularHeartCardiogenesisTranscription factors/regulators Cell CycleCell DivisionSpindle EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors NeuroscienceCell Type MarkerGlia markerOligodendrocyte marker Stem CellsSignaling PathwaysWntCytoplasmic Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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