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| 品牌 | absin | CAS | 9012-76-4 |
|---|---|---|---|
| 分子式 | C6H11NO4X2 | 分子量 | 150000 |
| 货号 | abs47027842 | 规格 | 2mg |
| 供货周期 | 现货 | 主要用途 | is a linear polysaccharide |
| 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Chitosan 9012-76-4
| 产品描述 | |
| 描述 | Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 壳聚糖；Deacetylated chitin；Poly(D-glucosamine) |
| 外观 | 白色或灰白色的半透明片状固体 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | Antibacterial |
| In vitro(体外研究) | Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan is reported to have other biological properties, such as antitumor, antimicrobial, and antioxidant activities. It can be used in water treatment, wound-healing materials, pharmaceutical excipient or drug carrier, obesity treatment and as a scaffold for tissue engineering. Antimicrobial activity of chitosan has been demonstrated against many bacteria, filamentous fungi and yeasts. Chitosan has wide spectrum of activity and high killing rate against Gram-positive and Gram-negative bacteria, but lower toxicity toward mammalian cells. Chitosan exhibits antitumor activity against different types of cancer. For example, chitosan decreases adhesion of primary melanoma A375 cell line and decreases proliferation of primary melanoma SKMEL28 cell line, it has potent pro-apoptotic effects against RPMI7951, a metastatic melanoma cell line. Chitosan and its derivatives act as antioxidants by scavenging oxygen radicals such as hydroxyl, superoxide, alkyl as well as highly stable DPPH radicals in vitro. |
| In vivo(体内研究) | Chitosan treatment dramatically increases lifespan and inhibits tumor metastasis especially in treatment groups of the low-molecular weight compound. Chitosan has some apparent treatment effects on rat PCP by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL-10 and IFN-γ as well as CD4(+) T-lymphocyte numbers, reducing the CD8(+) T-lymphocyte numbers and the concentration of TNF-α and inducing significant ultrastructural damage to P. carinii. |
| 研究领域 | |
| 研究领域 | CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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