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| 品牌 | absin | CAS | 1129669-05-1 |
|---|---|---|---|
| 分子式 | C22H20FN3O2 | 纯度 | ＞98% |
| 分子量 | 377.41 | 货号 | abs810638 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | IM-12 is a selective GSK-3β inhibitor w | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
IM-12 1129669-05-1
| 产品描述 | |
| 描述 | The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | The GSK3β Inhibitor XIX, IM 12, IM-12,IM12 |
| 外观 | Powder |
| 可溶性/溶解性 | Ethanol ：10 mg/mL (26.49 mM) warmed DMSO ：70 mg/mL (185.5 mM) |
| 生物活性 | |
| 靶点 | GSK-3β |
| In vitro(体外研究) | In hNPCs, IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly. Through the activation of canonical Wnt signalling pathway, IM-12 promotes the neuronal differentiation of human neural progenitor cells. |
| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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