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| 品牌 | absin | CAS | 667463-85-6 |
|---|---|---|---|
| 分子式 | C18H12BrN3O3 | 纯度 | ＞98% |
| 分子量 | 398.21 | 货号 | abs810193 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective GSK-3 inhibit | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
BIO-Acetoxime 667463-85-6
| 产品描述 | |
| 描述 | BIO-acetoxime (BIA) is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. BIO-acetoxime has anticonvulsant and anti-infection activity. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | BIA；GSK3 Inhibitor X6-Bromoindirubin-3'-acetoxime |
| 外观 | dark red to purple powder |
| 可溶性/溶解性 | DMSO : 20.83 mg/mL (52.31 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | GSK-3α；GSK-3β |
| In vitro(体外研究) | BIO-acetoxime (BIA; Compound 13) is a potent and selective GSK-3α/β inhibitor, with IC50s of both 10 nM. BIO-acetoxime (BIA) shows weak effect on CDK5/p35 (IC50, 2.4 μM), CDK2/cyclin A (IC50, 4.3 μM), and CDK1/cyclin B (IC50, 63 μM). BIO-acetoxime (BIA) (5 μM and 10 μM) increases the viability of HSV-1-infected cells but shows little effect on morphology and viability of mockin-fected cells. Moreover, BIO-acetoxime (BIA) (0.625, 1.25, 2.5, 5, and 10 μM) significantly reduces the release of HSV-1 particles in OC3 cells, with an EC50 of 0.68 ± 0.28 μM. BIO-acetoxime (BIA) inhibits the expression of HSV-1 genes, and may not affect the nuclear targeting of HSV-1 capsids. In addition, delayed addition of BIO-acetoxime (BIA) also inhibits HSV-1 infection. |
| In vivo(体内研究) | BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration. |
| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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