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Product Category详细介绍
| 品牌 | absin | CAS | 1334921-03-7 |
|---|---|---|---|
| 分子式 | C24H21N3O3S | 纯度 | 98% |
| 分子量 | 431.51 | 货号 | abs47028307 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent and specific Hec1 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
TAI-1 1334921-03-7
| 产品描述 | |
| 描述 | TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:86 mg/mL (199.3 mM) |
| 生物活性 | |
| 靶点 | Hec1 |
| In vitro(体外研究) | TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells. |
| In vivo(体内研究) | TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell division Cell CycleCell Division Cell CycleKinases/PhosphatasesOther Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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