SB273005 205678-31-5

简要描述：SB273005 205678-31-5
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.

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品牌	absin	CAS	205678-31-5
分子式	C22H24F3N3O4	纯度	98%
分子量	451.44	货号	abs47028306
规格	5mg	供货周期	现货
主要用途	is a potent integrin inhibitor	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

SB273005 205678-31-5

产品描述
描述	SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	DMSO:90 mg/mL warmed (199.36 mM)
生物活性
靶点	αvβ5 receptor ,αvβ3 receptor
In vitro(体外研究)	In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM).
In vivo(体内研究)	In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels.
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参考文献

研究领域
研究领域	Signal TransductionCytoskeleton / ECMCytoskeleton Drug DiscoverySmall Molecule DrugLead Compound Discovery

SB273005 205678-31-5温馨提示：本产品仅作科研实验使用，不支持临床等研究

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