Splitomicin 5690-03-9

简要描述：Splitomicin 5690-03-9
Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.

产品型号：abs47028308
厂商性质：生产厂家
更新时间：2026-01-28
访问量：922

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生化试剂

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详细介绍

品牌	absin	CAS	5690-03-9
分子式	C13H10O2	纯度	＞98%
分子量	198.22	货号	abs47028308
规格	10mg	供货周期	现货
主要用途	is a selective NAD(+)-dependent histone	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Splitomicin 5690-03-9

产品描述
描述	Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	斯普利特麻一辛
外观	Powder
可溶性/溶解性	DMSO : 19.8 mg/mL (100 mM) Ethanol : 19.8 mg/mL (100 mM)
生物活性
靶点	Sir2p
In vitro(体外研究)	Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. [1] Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release.
In vivo(体内研究)	In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation.
参考文献
参考文献	1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118. 2. Liu FC, et al. Thromb Res. 2009, 124(2), 199-207.

研究领域
研究领域	CancerCancer Metabolism CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery

Splitomicin 5690-03-9温馨提示：本产品仅作科研实验使用，不支持临床等研究

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下一篇：abs47028309EI1 1418308-27-6

Splitomicin 5690-03-9

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