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| 品牌 | absin | CAS | 959763-06-5 |
|---|---|---|---|
| 分子式 | C19H18ClN5O2S | 纯度 | 98% |
| 分子量 | 415.9 | 货号 | abs47028305 |
| 规格 | 1mg | 供货周期 | 现货 |
| 主要用途 | is an orally available Hsp90 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
CH5138303 959763-06-5
| 产品描述 | |
| 描述 | CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:83 mg/mL (199.56 mM) |
| 生物活性 | |
| 靶点 | HSP90α |
| In vitro(体外研究) | CH5138303 shows high affinity to Hsp90αand potent cell growth inhibitory activity against an HCT116 colorectal cancer cell line and an NCI-N87 gastric cancer cell line with IC50 of 98 nM and 66 nM, respectively. Besides, CH5138303 also demonstrates liver microsomal stability. |
| In vivo(体内研究) | CH5138303 (50 mg/kg p.o.) displays high oral bioavailability in mice and produces potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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