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Product Category详细介绍
| 品牌 | absin | CAS | 1095253-39-6 |
|---|---|---|---|
| 分子式 | C28H24Cl2FN5O2 | 纯度 | 98% |
| 分子量 | 552.43 | 货号 | abs47028304 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an allosteric, and selective Eg5 mit | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
ARQ 621 1095253-39-6
| 产品描述 | |
| 描述 | ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | ARQ-621 |
| 外观 | White to off-white Powder |
| 可溶性/溶解性 | DMSO : 93 mg/mL (168.35 mM) |
| 生物活性 | |
| 靶点 | Eg5 mitotic motor protein |
| In vitro(体外研究) | ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. |
| In vivo(体内研究) | ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerCancer Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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