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| 品牌 | absin | CAS | 152044-53-6 |
|---|---|---|---|
| 分子式 | C26H39NO6S | 纯度 | 98% |
| 分子量 | 493.66 | 货号 | abs47028302 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a Taxol-like microtubule-stabilizing | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Epothilone A 152044-53-6
| 产品描述 | |
| 描述 | Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 埃博霉素 A |
| 外观 | White to beige powder |
| 可溶性/溶解性 | DMSO : 92 mg/mL (186.4 mM) Ethanol : 92 mg/mL (186.4 mM) |
| 生物活性 | |
| 靶点 | Tubulin |
| In vitro(体外研究) | Epothilone A, discovered from the myxobacterium Sorangium cellulosum, is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.Epothilone A potently inhibits cell proliferation in HCT116 cells, with IC50 of 4.4 nM. Epothilone A also displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 values ranging from 13 nM to 160 nM. Epothilone A is more water soluble than Taxol and competes with Taxol in binding with microtubules, with IC50 of 2.3 μM. However, both Epothilone A and Taxol don't share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently. Recently, it is found that microbiological transformation of Epothilone A by Aspergillus niger AS 3.739 yields several metabolites that is also toxic to MCF-7 cells, but with much higher IC50 values. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | NeuroscienceCell Type MarkerNeuron markerAxon marker Signal TransductionCytoskeleton / ECMCytoskeletonMicrotubulesTubulin Tags & Cell MarkersSubcellular MarkersCytoskeletonMicrotubules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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