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| 品牌 | absin | CAS | 848141-11-7 |
|---|---|---|---|
| 分子式 | C25H22F3N5O4S | 分子量 | 545.53 |
| 货号 | abs47028234 | 规格 | 10mg |
| 供货周期 | 现货 | 主要用途 | is an oral, highly selective inhibitor |
| 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Alvelestat 848141-11-7
| 产品描述 | |
| 描述 | Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | AZD9668 |
| 外观 | White Solid |
| 可溶性/溶解性 | DMSO : 40 mg/mL (73.32 mM) |
| 生物活性 | |
| 靶点 | neutrophil elastase ,neutrophil elastase |
| In vitro(体外研究) | AZD9668 inhibits plasma NE activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells. |
| In vivo(体内研究) | In mice and rats, AZD9668 (p.o.) prevents human NE-induced lung injury. In a mouse model of smoke-induced airway inflammation, AZD9668 significantly reduces the number of BAL neutrophils and BAL IL-1β. In a guinea pig chronic smoke model, AZD9668 prevents airspace enlargement and small airway wall remodeling in guinea pigs in response to chronic tobacco smoke exposure. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Proteolysis / UbiquitinProteasome / Ubiquitin Signal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsCollagen Signal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsElastin Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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