全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 178946-89-9 |
|---|---|---|---|
| 分子式 | C23H17ClN2 | 纯度 | 98% |
| 分子量 | 356.85 | 货号 | abs47028233 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | induced expression of Nurr1-regulated ge | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
C-DIM12 178946-89-9
| 产品描述 | |
| 描述 | C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外观 | Orange solid |
| 可溶性/溶解性 | N/A |
| 生物活性 | |
| 靶点 | Nurr1 |
| In vitro(体外研究) | C-DIM12 induces Nurr1 and DA gene expression in cell lines and primary neurons. C-DIM12 suppresses astrocyte inflammatory signaling in vitro. C-DIM12 inhibits lipopolysaccharide (LPS)–induced expression of NF-κB-regulated genes in BV-2 microglia including nitric oxide synthase (NOS2), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2), and the effects were attenuated by Nurr1-RNA interference. Additionally, C-DIM12 decreased NF-κB activation in NF-κB–GFP (green fluorescent protein) reporter cells and enhanced nuclear translocation of Nurr1 primary microglia. C-DIM12 decreases lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2). |
| In vivo(体内研究) | C-DIM12 has the neuroprotective activity in MPTPp-treated mice. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismResponse to hypoxia EpigeneticsTranscriptionOther factors ImmunologyImmune System DiseasesAutoimmune MetabolismPathways and ProcessesMetabolism processesHypoxia NeuroscienceProcesses NeuroscienceNeurology processNeural Signal Transduction NeuroscienceNeurology processNeurogenesis NeuroscienceNeurology processNeurodegenerative diseaseParkinson's diseaseOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：