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| 品牌 | absin | CAS | 1493764-08-1 |
|---|---|---|---|
| 分子式 | C25H33N7O2 | 纯度 | 98% |
| 分子量 | 463.58 | 货号 | abs47028113 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a specific Mer tyrosine kinase inhib | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
UNC2881 1493764-08-1
| 产品描述 | |
| 描述 | UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 200 mM in DMSO |
| 生物活性 | |
| 靶点 | Mer ,Tyro3 ,Axl |
| In vitro(体外研究) | UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. |
| In vivo(体内研究) | UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCell cycleKinases/phosphatasesOther CancerOncoproteins/suppressorsOncoproteinsSignal transducers CancerSignal transductionOther Cell CycleKinases/PhosphatasesOther NeuroscienceProcesses Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Tags & Cell MarkersCell Type MarkersTumor Associated Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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