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| 品牌 | absin | CAS | 1668553-26-1 |
|---|---|---|---|
| 分子式 | C46H55N7O7S | 纯度 | 99% |
| 分子量 | 850.04 | 货号 | abs47028115 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective MCL-1 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
A-1210477 1668553-26-1
| 产品描述 | |
| 描述 | A-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | MCL-1 |
| In vitro(体外研究) | In H929 cells, A-1210477 binds to MCL-1 with high affinity and induces MCL-1 protein elevation. In H929, H2110, and H23 cells, A-1210477 induce the hallmarks of apoptosis, and inhibits MCL-1-dependent cell viability. A-1210477 also synergizes with navitoclax to kill a variety of cancer cell lines. In SKBR3 cells, A-1210477 inhibits MCL-1–BIM interaction and induces classical features of apoptosis. In addition, A-1210477 sensitizes non-Hodgkin's lymphoma cell lines to venetoclax (ABT-199). |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCancer MetabolismCellular metabolic process CancerCancer MetabolismResponse to hypoxia CancerCell DeathApoptosisMetabolism CancerCell DeathApoptosisApoptosis MarkersBcl 2 family CancerInvasion/microenvironmentApoptosisBcl 2 family CancerOncoproteins/suppressorsOncoproteinsCell survival & death CancerTumor biomarkersOncoproteins ApoptosisIntracellularBcl2 Family MetabolismTypes of diseaseCancer MetabolismPathways and ProcessesMetabolism processesApoptosis MetabolismPathways and ProcessesMetabolism processesHypoxia MetabolismPathways and ProcessesMitochondrial MetabolismMitochondrial markers Signal TransductionMetabolismMitochondrial Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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