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简要描述：AG-337;Nolatrexed dihydrochloride 152946-68-4Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
产品型号：abs47028112厂商性质：生产厂家更新时间：2026-01-19访 问 量：604产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 152946-68-4 |
|---|---|---|---|
| 分子式 | C14H14Cl2N4OS | 纯度 | C14H14Cl2N4OS 分子量： 357.26 纯度/级别： 98% |
| 分子量 | 357.26 | 货号 | abs47028112 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is the dihydrochloride salt of nolatrex | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
AG-337;Nolatrexed dihydrochloride 152946-68-4
| 产品描述 | |
| 描述 | Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸诺拉曲塞；二盐酸诺拉曲塞 |
| 外观 | Off-White to Pale Yellow Solid |
| 可溶性/溶解性 | DMSO > 10 mM |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | EpigeneticsDNA / RNADNA SynthesisOther MetabolismPathways and ProcessesMetabolic signaling pathwaysNucleotide metabolismPurine and pyrimidine synthesis Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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