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| 品牌 | absin | CAS | 176161-24-3 |
|---|---|---|---|
| 分子式 | C15H19Cl2N3O4 | 纯度 | 98% |
| 分子量 | 376.235 | 货号 | abs47027923 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is by inhibition of an HCMV encoded pro | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Maribavir 176161-24-3
| 产品描述 | |
| 描述 | Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 马立巴韦; 1263W94；BW1263W94； GW257406X |
| 可溶性/溶解性 | DMSO : 200 mg/mL (531.58 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | CMV |
| In vitro(体外研究) | Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a Ki of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM. |
| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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