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| 品牌 | absin | CAS | 129-46-4 |
|---|---|---|---|
| 分子式 | C51H34N6Na6O23S6 | 纯度 | ＞98% |
| 分子量 | 1429.15 | 货号 | abs47027921 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is a polysulfonated naphthylurea | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Suramin Sodium Salt 129-46-4
| 产品描述 | |
| 描述 | Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM). |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 苏拉明钠; Suramin hexasodium salt；BAY-205；NF-060 |
| 外观 | White Crystalline Powder |
| 可溶性/溶解性 | H2O : ≥ 200 mg/mL (139.94 mM) DMSO : 5.6 mg/mL (3.92 mM; Need warming) |
| 生物活性 | |
| 靶点 | P2Y Receptor |
| In vitro(体外研究) | Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 µM) than is DNA polymerase δ (IC50=36 µM), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 µM). Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM. |
| In vivo(体内研究) | Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen. |
| 研究领域 | |
| 研究领域 | ApoptosisIntracellularp53 Pathway EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass III / Sir2 class MetabolismTypes of diseaseObesity MicrobiologyInterspecies InteractionHost Virus Interaction Tags & Cell MarkersSubcellular MarkersNucleusOther Nuclear Bodies Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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