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| 品牌 | absin | CAS | 28822-58-4 |
|---|---|---|---|
| 分子式 | C10H14N4O2 | 纯度 | 99% |
| 分子量 | 222.24 | 货号 | abs47027840 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is a potent cyclic nucleotide phosphodie | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
IBMX 28822-58-4
| 产品描述 | |
| 描述 | IBMX is a potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 3-异丁基-1-甲基黄piao呤; NSC165960；SC2964；IBMX；Isobutylmethylxanthine |
| 外观 | Off-white powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (224.98 mM) Ethanol : ≥ 7.14 mg/mL (32.13 mM) |
| 生物活性 | |
| 靶点 | Phosphodiesterase (PDE) |
| In vitro(体外研究) | At 100 μM, KMUP-1 (a xanthine derivative) and IBMX are the most effective at inducing tracheal relaxation; the magnitude of the relaxation responses induced by KMUP-1 and IBMX are not significantly different. IBMX (100 μM) activates renal outer medullary K+ (ROMK) channels (n=6, P+ (HK)-fed rats with IBMX (100 μM) for 20 min leads to a significant increase in tubular cAMP content to 1.43±0.35 pg/mm tubule length (n=14) compare with that measured in vehicle-treated controls (0.61±0.13 pg/mm tubule length, n=12, P. |
| In vivo(体内研究) | IBMX, a non-selective PDE inhibitor significantly decreases the liver glycogen storage (mg/g, IBMX 22±1.5 P0.05) also mc2 does not change plasma glucose (control=141±3 and mc2=145±5). IBMX has the highest efficacy on increasing plasma glucose. Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats. |
| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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