2'-Deoxyinosine 890-38-0

简要描述：2'-Deoxyinosine 890-38-0
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond.

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2'-Deoxyinosine 890-38-0

产品描述
描述	2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	2'-脱氧肌gan
外观	白色粉末
可溶性/溶解性	10 mM in DMSO
生物活性
In vitro(体外研究)	In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals.
参考文献
参考文献	1. Baumann T, et al. BMC Biotechnol. 2013 Oct 4;13:81. 2. Zhang J, et al. Chem Commun (Camb). 2010 Oct 7;46(37):6986-8. 3. K?stler K, et al. Chem Biodivers. 2013 Jan;10(1):39-61.

研究领域
研究领域	Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery

2'-Deoxyinosine 890-38-0温馨提示：本产品仅作科研实验使用，不支持临床等研究

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