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| 品牌 | absin | CAS | 19542-67-7 |
|---|---|---|---|
| 分子式 | C10H9NO2S | 纯度 | >98 % |
| 分子量 | 207.25 | 货号 | abs810013 |
| 规格 | 5mg;10mg;25mg | 供货周期 | 现货 |
| 主要用途 | Also inhibiting components of the ubiqui | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
| 产品描述 | |
| 描述 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system. |
| 纯度 | >98 % |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | BAY11-7082；BAY117082 |
| 外观 | White to off white solid |
| 可溶性/溶解性 | DMSO ：41 mg/mL (197.82 mM) Ethanol ：10 mg/mL (48.25 mM) |
| 生物活性 | |
| 靶点 | E2-conjugating enzymes；IκBα phosphorylation |
| In vitro(体外研究) | Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules. |
| In vivo(体内研究) | BAY 11-7082 (2.5 mg/kg and 5 mg/kg; intratumoral injection; twice-weekly for 21 days ) significantly suppresses tumor growth in a dose-dependent manner. |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell cycle inhibitorsp53 pathway Cell CycleCell Cycle Inhibitorsp53 Proteolysis / UbiquitinProteasome / UbiquitinDeubiquitination EpigeneticsUbiquitin & Ubiquitin Like ModifiersDeubiquitination MicrobiologyInterspecies InteractionHost Virus Interaction Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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