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| 品牌 | absin | CAS | 48208-26-0 |
|---|---|---|---|
| 分子式 | C19H14N2O4 | 纯度 | ＞98% |
| 分子量 | 334.33 | 货号 | abs810498 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is an inhibitor of DNA methyltransferase | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
RG108 48208-26-0
| 产品描述 | |
| 描述 | RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | RG-108，RG 108，N-Phthalyl-L-tryptophan |
| 外观 | Powder |
| 可溶性/溶解性 | Ethanol ：33.4 mg/mL (100 mM) DMSO ：33.4 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | DNA methyltransferase |
| In vitro(体外研究) | RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs. |
| 研究领域 | |
| 研究领域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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