全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 355025-24-0 |
|---|---|---|---|
| 分子式 | C23H23ClN2O5S | 纯度 | ＞98% |
| 分子量 | 474.96 | 货号 | abs810488 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a competitive, potent and reversible | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Ki-16425 355025-24-0
| 产品描述 | |
| 描述 | Ki-16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Debio 0719；Ki16425 |
| 外观 | white powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (210.54 mM) |
| 生物活性 | |
| 靶点 | LPL Receptor |
| In vitro(体外研究) | Ki-16425 (10 μM; 1.5 hours; HEK293A cells) treatment blocks LPA-induced dephosphorylation of YAP/TAZ in HEK293A cells. Ki16425 partially inhibits the ability of serum to repress YAP/TAZ phosphorylation, particularly at low serum concentrations (0.2%). |
| In vivo(体内研究) | Ki-16425 (Debio 0719) (1-30 mg/kg; i.p.; at 30 min prior to LPA injection) inhibits LPA-induced neuropathic pain-like behaviors. |
| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：