SF1670 345630-40-2

简要描述：SF1670 345630-40-2
SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。

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详细介绍

SF1670 345630-40-2

产品描述
描述	SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
外观	Red-violet solid
可溶性/溶解性	DMSO ：30.7 mg/mL (100 mM)
生物活性
靶点	PTEN
In vitro(体外研究)	SF1670 shows potent cytotoxicity in HBEC, PC-3, H1299 cells with IC50 of 5 μM, 10 μM, 44 μM, respectively. In a mouse aortic ring matrigel angiogenesis model, SF1670 stimulates the angiogenic processes. SF1670 augments chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil functions.
In vivo(体内研究)	Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia.

研究领域

CancerCell cycleKinases/phosphatasesPhosphatases

CancerOncoproteins/suppressorsTumor suppressorsPTEN pathway

Cell CycleKinases/PhosphatasesPhosphatases

EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors

MetabolismTypes of diseaseDiabetes

MetabolismTypes of diseaseMetabolic disorders

MetabolismTypes of diseaseObesity

NeuroscienceDevelopment

Signal TransductionSignaling PathwayLipid SignalingLipid Phosphatases

Drug DiscoverySmall Molecule DrugLead Compound Discovery

SF1670 345630-40-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

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