全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 853625-60-2 |
|---|---|---|---|
| 分子式 | C24H20N4O4S | 纯度 | ＞98% |
| 分子量 | 460.5 | 货号 | abs47028408 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a selective cytohesin inhibitor with | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
SecinH3 853625-60-2
| 产品描述 | |
| 描述 | SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | N-(4-(5-(benzo[d][1,3]dioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide |
| 外观 | 白色固体 |
| 可溶性/溶解性 | DMSO : 46.1 mg/mL (100 mM) Ethanol : 4.6 mg/mL (10 mM), with gentle warming |
| 生物活性 | |
| 靶点 | hCyh2,hCyh1,mCyh3,hCyh3,drosophila steppke,, |
| In vitro(体外研究) | In HepG2 cells, SecinH3 inhibits insulin signaling and associated gene expression. SecinH3 also markedly inhibits migration of preadipocyte 3T3-L1 cells. In the A549 cells, SecinH3 results in reduced proliferation by indirectly attenuating EGFR activation, and causes a synergistic antiproliferative effect when used in combination with gefitinib. |
| In vivo(体内研究) | In mice, SecinH3 increases the expression of gluconeogenic genes, reduces the expression of glycolytic, fatty acid and ketone body metabolism genes in the liver, reduces liver glycogen stores, and increases plasma insulin. In mice bearing H460 xenografts, SecinH3 significantly retards tumor growth through its antiproliferative and pro-apoptotic effect. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Metabolism CancerCancer Metabolism NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：