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| 品牌 | absin | CAS | 845273-93-0 |
|---|---|---|---|
| 分子式 | (C3H7N.C3H5ClO)x.xCH2O3 | 纯度 | 98% |
| 分子量 | N/A | 货号 | abs47028395 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is a non-absorbed phosphate binding cro | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Sevelamer Carbonate 845273-93-0
| 产品描述 | |
| 描述 | Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:0.05 mg/mL 0.05 |
| 生物活性 | |
| In vitro(体外研究) | Sevelamer carbonate is designed as an alternative to sevelamer hydrochloride with enhanced buffering capacity. The sevelamer moiety consists of a carbon backbone with multiple amine groups, each separated from the backbone by a single carbon atom. In the intestine, Sevelamer carbonate become protonated and subsequently bind to dietary phosphorus molecules via ionic and hydrogen interactions. The result of these interactions is a decrease in phosphorus levels within the gastrointestinal tract, resulting in decreased dietary phosphorus absorption and decreased serum phosphorus levels. In addition to the effect on phosphorus levels, the polymeric amine structure of sevelamer has been shown to bind bile acids to reduces total cholesterol levels. |
| In vivo(体内研究) | Sevelamer Carbonate is able to reduce renal failure triggered inflammation and induced endotoxemia in experimental model of chronic kidney disease. Sevelamer carbonate also shows beneficial effects on renal dysfunction, secondary hyperparathyroidism and vascular calcification in rats fed with high-phosphorus diet. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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