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| 品牌 | absin | CAS | 40828-46-4 |
|---|---|---|---|
| 分子式 | C14H12O3S | 纯度 | 99% |
| 分子量 | 260.31 | 货号 | abs47028393 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | used as a non-steroidal anti-inflammator | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Suprofen 40828-46-4
| 产品描述 | |
| 描述 | Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 舒洛芬 |
| 外观 | 白色至类白色粉末 |
| 可溶性/溶解性 | DMSO:52 mg/mL (199.76 mM) |
| 生物活性 | |
| 靶点 | COX-1,COX-2 |
| In vitro(体外研究) | Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). |
| In vivo(体内研究) | Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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