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| 品牌 | absin | CAS | 1004316-88-4 |
|---|---|---|---|
| 分子式 | C40H53N7O5S2 | 纯度 | 98% |
| 分子量 | 776.02 | 货号 | abs47028283 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective inhibitor of C | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cobicistat 1004316-88-4
| 产品描述 | |
| 描述 | Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 可比司他; GS-9350 |
| 外观 | Off-white solid |
| 可溶性/溶解性 | DMSO : 250 mg/mL (322.16 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | Cytochrome P450 |
| In vitro(体外研究) | Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30 μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir. Cobicistat is a novel cytochrome P450 3A4 inhibitor in advanced clinical evaluation for use as a pharmacoenhancer of antiretroviral drugs. It lacks significant anti-HIV activity and is more selective than ritonavir in its enzyme inhibition. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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