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| 品牌 | absin | CAS | 1034616-18-6 |
|---|---|---|---|
| 分子式 | C24H27F3N8O3 | 纯度 | 98% |
| 分子量 | 532.52 | 货号 | abs47028284 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is an orally available | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
NMS-P937 1034616-18-6
| 产品描述 | |
| 描述 | NMS-P937 (NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Phase 1. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Onvansertib；NMS-1286937 |
| 外观 | White to off white powder |
| 可溶性/溶解性 | DMSO : 21 mg/mL (39.44 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | PLK1 |
| In vitro(体外研究) | NMS-P937 shows a broad-spectrum antiproliferative activity against different solid tumor, leukemias and lymphomas cell lines. NMS-P937 potently causes a mitotic cell-cycle arrest followed by apoptosis in A2780 cells. |
| In vivo(体内研究) | In mice xenografted with human HCT116 colon adenocarcinoma cells, NMS-P937 (90 mg/kg/d i.v. or p.o.) shows a significant tumor growth inhibition. In mice bearing HT29, Colo205 colorectal, or A2780 ovarian xenograft tumors, NMS-P937 inhibits xenograft tumor growth. In addition, NMS-P937, in combination with approved cytotoxic drugs, causes enhanced tumor regression, and prolongs survival of animals. |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell division Cell CycleCell DivisionSpindle Cell CycleKinases/PhosphatasesOther EpigeneticsCell cycleKinases/PhosphatasesOther NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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