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| 品牌 | absin | CAS | 1217022-63-3 |
|---|---|---|---|
| 分子式 | C17H13Br2N5OS.HBr | 纯度 | 98% |
| 分子量 | 576.10 | 货号 | abs47028273 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is the hydrobromide salt of PTC-209 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
PTC-209 HBr 1217022-63-3
| 产品描述 | |
| 描述 | PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs). |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:100 mg/mL warmed (173.58 mM) |
| 生物活性 | |
| 靶点 | BMI-1 |
| In vitro(体外研究) | PTC-209 inhibits both the UTR-mediated reporter expression and endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells. PTC-209 decreases colorectal tumor cell growth in a BMI-1-dependent way. In addition, PTC-209 impairs colorectal cancer-initiating cells (CICs) through irreversible growth inhibition. |
| In vivo(体内研究) | PTC-209 (60 mg/kg/day, s.c.) effectively inhibits BMI-1 production in tumor tissue, and halts growth of preestablished tumors in mice bearing primary human colon cancer xenograft, human colon cancer cell lines LIM1215 or HCT116 xenografts. PTC-209 also reduces the frequency of functional colorectal CICs in vivo. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCancer Metabolism CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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