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| 品牌 | absin | CAS | 377090-84-1 |
|---|---|---|---|
| 分子式 | C13H11N3O2 | 纯度 | 98% |
| 分子量 | 241.25 | 货号 | abs47028272 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a 3-substituted indolinone CDK inhibi | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
SU9516 377090-84-1
| 产品描述 | |
| 描述 | SU 9516 is a 3-substituted indolinone CDK inhibitor with IC50 of 22 nM, 40 nM, and 200 nM for CDK2, CDK1, and CDK4, respectively. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | SU-9516；SU 9516 |
| 外观 | yellow to orange powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (414.51 mM) |
| 生物活性 | |
| 靶点 | CDK2 ,CDK1,CDK4 |
| In vitro(体外研究) | SU9516 decreases cdk2-specific phosphorylation of the retinoblastoma protein pRB, increases caspase-3 activation, and alters cell cycle in RKO and SW480 cells. SU9516 also inhibits the cell proliferation, and induces cell apoptosis in both cell lines. SU9516 kills leukemic cells through inhibition of RNA Pol II CTD phosphorylation, oxidative damage and transcriptional down-regulation of Mcl-1. In human T-cell leukemia Jurkat cells, SU9516 significantly enhances sensitivity to methotrexate. In addition, SU9516 also suppresses Aurora-A centrosomal localization and consequent centrosome amplification. |
| 研究领域 | |
| 研究领域 | CancerCell cycleKinases/phosphatasesCdks Cell CycleKinases/PhosphatasesCdks EpigeneticsCell cycleKinases/PhosphatasesCdks Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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