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Product Category详细介绍
| 品牌 | absin | CAS | 1369761-01-2 |
|---|---|---|---|
| 分子式 | C20H28ClN7O3S | 纯度 | 98% |
| 分子量 | 482 | 货号 | abs47028259 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is an oral active | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cerdulatinib (PRT062070, PRT2070) 1369761-01-2
| 产品描述 | |
| 描述 | Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:43 mg/mL warmed (89.21 mM) |
| 生物活性 | |
| 靶点 | TYK2 ,MST1 ,ARK5 ,MLK1 ,Fms |
| In vitro(体外研究) | In human whole blood from normal donors, Cerdulatinib affects BCR-mediated B-cell activation by dual inhibition of SYK and JAK. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. |
| In vivo(体内研究) | In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg p.o.) significantly improves inflammatory infiltrate within the synovium and the integrity of the articular cartilage. In addition, Cerdulatinib also blocks BCR-induced B-cell activation and splenomegaly in mice. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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