Cabotegravir 1051375-10-0

简要描述：Cabotegravir 1051375-10-0
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes

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品牌	absin	CAS	1051375-10-0
分子式	C19H17F2N3O5	纯度	98%
分子量	405.35	货号	abs47028258
规格	10mg	供货周期	现货
主要用途	is a long-acting HIV integrase inhibito	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Cabotegravir 1051375-10-0

产品描述
描述	Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	卡博特韦; GSK-1265744； S/GSK1265744
外观	White off off white crystalline powder
可溶性/溶解性	DMSO : 16.67 mg/mL (41.12 mM; Need ultrasonic)
生物活性
靶点	HIV integrase
In vitro(体外研究)	GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432, respectively. GSK1265744 produces cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μM in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, respectively.
In vivo(体内研究)	GSK1265744 (50 mg/kg) treatment protects rhesus macaques against three high-dose SHIV challenges.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Cabotegravir 1051375-10-0温馨提示：本产品仅作科研实验使用，不支持临床等研究

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