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| 品牌 | absin | CAS | 59-00-7 |
|---|---|---|---|
| 分子式 | C10H7NO4 | 纯度 | 98% |
| 分子量 | 205.17 | 货号 | abs47028212 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a chemical | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Xanthurenic Acid 59-00-7
| 产品描述 | |
| 描述 | Xanthurenic acid, or xanthurenate, is a chemical shown to induce gametogenesis of Plasmodium falciparum, the parasite that causes malaria. It is found in the gut of the Anopheles mosquito. Xanthurenic acid is a metabolic intermediate that accumulates and is excreted by pyridoxine (vitamin B6) deficient animals after the ingestion of tryptophan. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 4,8-二羟基喹啉-2-甲酸；黃尿酸 |
| 外观 | Yellow to brown powder |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | mGlu2 ,mGlu3 |
| In vitro(体外研究) | Xanthurenic acid (XA) is considered as a putative neurotransmitter in the CNS, being stored in synaptic vesicles and released by membrane depolarization in a Ca2+-dependent fashion. It is known to inhibit vesicular glutamate transporters (VGLUTs). In heterologous expression systems, Xanthurenic acid could activate both mGlu2 and mGlu3 receptors with high potency, but has no activity on mGlu4 and mGlu7 receptors. Xanthurenic acid induces cell death associated with caspase-3, -8, and -9 activation, nuclear DNA cleavage, and cytochrome C release while not associated with cytoskeleton breakdown -- apoptosis induced by xanthurenic acid does not cause cytoskeleton depolymerization. |
| In vivo(体内研究) | Systemic administration of Xanthurenic acid in mice produces antipsychotic-like effects in the MK-801-induced model of hyperactivity and peripheral xanthurenic acid can cross the blood-brain barrier, influence the activity of brain regions that are involved in the pathophysiology of schizophrenia. |
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| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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