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| 品牌 | absin | CAS | 504-88-1 |
|---|---|---|---|
| 分子式 | C3H5NO4 | 纯度 | ≥98% |
| 分子量 | 119.08 | 货号 | abs47028211 |
| 规格 | 100mg | 供货周期 | 现货 |
| 主要用途 | is an irreversible inhibitor of succinat | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Bovinocidin 504-88-1
| 产品描述 | |
| 描述 | Bovinocidin is an irreversible inhibitor of succinate dehydrogenase. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 3-硝基丙酸; 3-Nitropropanoic acid；β-Nitropropionic acid |
| 外观 | white to light yellow powder |
| 可溶性/溶解性 | DMSO : 125 mg/mL (1049.71 mM; Need ultrasonic) H2O : 100 mg/mL (839.77 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | Succinate dehydrogenase |
| In vitro(体外研究) | 3-nitropropionic acid (3-NPA) is an irreversible inhibitor of complex II in the mitochondria. It impairs cellular energy metabolism via inhibition of succinate dehydrogenase, which induces a reduction in ATP production and leads to oxidative stress. 3-NPA can cause the generation and release of ROS from mitochondria, mitochondrial DNA damage, and thus loss of mitochondrial function. 3-NPA reduces the number of large follicles, impairs oocyte development, and increases the percentage of atretic large follicles and ROS levels in oocytes and granulosa cells. ROS production followed by mitochondrial DNA damage is the primary event in 3-NPA toxicity, and Bcl-2 protects PC12 cells from 3-NPA toxicity by preventing mitochondrial DNA damage. |
| In vivo(体内研究) | 3-NPA induces granulosa cell apoptosis, large follicle atresia, and an increase of ROS levels in the ovary. |
| 研究领域 | |
| 研究领域 | Metabolism MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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