全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 860-79-7 |
|---|---|---|---|
| 分子式 | C26H46N2O | 纯度 | 98% |
| 分子量 | 402.66 | 货号 | abs47028196 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | Extracted from Buxus microphylla | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cyclovirobuxin D 860-79-7
| 产品描述 | |
| 描述 | Extracted from Buxus microphylla;Suitability:Chloroform,methanol and ethanol;Store the product in sealed,cool and dry condition |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Cyclovirobuxine D increases cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduces the infarct size induced by ligating the coronary artery in rats. In addition, Cyclovirobuxine D protects rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells. Cyclovirobuxine D facilitates the utilization of intracellular Ca(2+) and prevents the loss of Ca(2+), which may be the underlying mechanism of its protective effect on heart failure. |
| In vivo(体内研究) | Cyclovirobuxine D decreases the weight of venous thrombus in rats. Cyclovirobuxine D causes a primary effect of coronary vasodilatation in anesthetized pigs, which involves mechanisms related to the endothelial release of nitric oxide. In addition, Cyclovirobuxine D is beneficial for heart failure in rats induced by myocardial infarction. LD50: Mice 8.9mg/kg (i.v.), 9.2mg/kg (i.p.), 293mg/kg (i.g.). |
| 参考文献 | |
| 参考文献 |
|
| 研究领域 | |
| 研究领域 | Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：