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| 品牌 | absin | CAS | 81-25-4 |
|---|---|---|---|
| 分子式 | C24H40O5 | 纯度 | 99% |
| 分子量 | 408.58 | 货号 | abs47028194 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | used for extraction of membrane proteins | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cholic Acid 81-25-4
| 产品描述 | |
| 描述 | ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins. ActionsBile AcidPackaging1 kg in poly bottle25,100,500 g in poly bottle |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 胆酸 |
| 外观 | 白色结晶粉末 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Fosfomycin is known to inhibit MurA by covalently binding to a highly conserved cysteine in the active site of the enzyme. Fosfomycin is a PEP mimetic that acts by alkylating the highly conserved Cys115 (Escherichia coli numbering) of MurA. Fosfomycin exerts immunomodulatory effects by altering lymphocyte, monocyte and neutrophil function. It affects the acute inflammatory cytokine response in vitro and in vivo. It suppresses production of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and IL-1α and increases production of IL-10. Fosfomycin suppresses IL-2 production from T cells, the production of leukotriene B4 (LTB4) from neutrophils, and the expression of IL-8 mRNA by LTB4 from monocytes. Fosfomycin also exhibits an immunomodulatory effect on B-cell activation. Fosfomycin enhances neutrophil phagocytic killing of invading pathogens, even in patients on chronic hemodialysis and renal transplantation. Fosfomycin resulted in enhanced bactericidal ability of neutrophils compared to other antimicrobials. Fosfomycin has the ability to penetrate into biofilms. fosfomycin is considerably active against both Gram-negative and Gram-positive pathogens. |
| In vivo(体内研究) | The oral bioavailability of fosfomycin trometamol ranges between 34 and 58%. Absorption occurs in the small intestine, and evidence suggests that coadministration of fosfomycin trometamol with food may reduce absorption of the drug.The mean serum elimination half-life (t1/2) of fosfomycin trometamol is estimated at 5.7 h. Fosfomycin is excreted nonmetabolized in the urine, through glomerular filtration. Depending on age, fasting, and renal function, 11 to 60% of the drug can be found in the urine within 24 h from administration. Specifically, older age, administration with a meal, and deteriorating renal function result in slower elimination through the kidneys. Fosfomycin crosses the blood-brain barrier, and meningeal inflammation increases its concentration in the CSF. Fosfomycin also penetrates in both cortical and cancellous bone, and penetration correlates with plasma levels and the presence of inflammation. |
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| 研究领域 | |
| 研究领域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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